Skin Irritation is the production of reversible inflammatory changes in the skin following the application of a test substance. The assessment of dermal irritation has typically involved the use of laboratory animals. As reproducibly shown EST1000 has proved to be suitable for identification and evaluation of hazards emanating from irritant compounds, avoiding animal experiments.

EST1000 is in the prevalidation phase and addresses the new UN-GHS classification. ECVAM acceptance for skin irritation testing is expected in the end of 2011.

CellSystems^® offers the “Skin Irritation Validation Kit” service to confirm interlaboratory reproducibility and to gain reliable results in your laboratory (see Validation Services).

CellSystems^® laboratory facility is DIN ISO 9001:2008 certified for skin model production and testing services.